Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is an orphan receptor that regulates the expression of genes involved in development and homeostasis.COUP-TFII is also dysregulated napoleon concealer in cancer, where it plays important roles in oncogenesis and malignant progression.Recent studies have also investigated altered microRNA-mediated regulation of COUP-TFII in cancer.Although many investigators have studied the expression and clinical significance of COUP-TFII in several cancer types, there remain many controversies regarding johnny cash style clothing its role in these diseases.In this review, we will describe the functions and underlying molecular mechanisms of COUP-TFII in several cancers, especially colorectal, gastric, breast, and prostate cancer; additionally, we will briefly summarize what is known about microRNA-mediated regulation of COUP-TFII.